This is also called a nonmyeloablative transplant, because the treatment used doesn’t completely destroy your bone marrow. As such, allogeneic transplants are usually not suitable for all patients.Ī “mini-allogeneic” or “reduced intensity” transplant uses less intensive and therefore less toxic chemotherapy. The complexities and risks may be increased even more with a mismatched or volunteer unrelated donor (VUD) transplant. They are complex procedures that carry significant risks. It is hoped that these cells will also attack and destroy all traces of the underlying disease.Īllogeneic transplants can offer the best chance of curing a number of blood and bone marrow cancers and other diseases. The cells of the donor’s immune system ( white blood cells) are transplanted along with the donor’s stem cells. In an allogeneic transplant the donor’s healthy stem cells are used to replace the patient’s unhealthy ones (which have been damaged by disease) by giving high doses of chemotherapy and radiotherapy used to treat the underlying disease. Sometimes there is a slight mismatch, but it may still be the best possible match for the patient. Where no sibling is available, a search is made of Australian and overseas donor registries to find a suitably matched unrelated stem cell donor. This is usually a sibling with the same tissue type as the patient. In an allogeneic transplant, stem cells are donated to the patient from another person who is a genetically matched stem cell donor. Your nurse will give you extra calcium through a drip if this happens.What is an allogeneic stem cell transplant? This happens if your calcium level gets low during your collection. You might feel very tired after having your stem cell collection. They are collected and frozen until after your high dose treatment. The machine filters the stem cells out of your blood. It goes through the machine and back into your body through the other drip. Your nurse puts a drip into each of your arms and attaches it to a machine. Collecting the stem cells takes 3 or 4 hours. When there are enough cells, your nurse collects them. On the collection dayĪfter your growth factor injections, you have blood tests every day to see if there are enough stem cells in your bloodstream. Sometimes you might have low doses of chemotherapy with the growth factor injections. You have daily injections of growth factor for between 5 and 10 days. Growth factors are natural proteins that make the bone marrow produce blood cells. You have injections of growth factors before, and sometimes after, the stem cell transplant. In some cancer centres, you may stay at home or in a hotel near the hospital for some of this time. It depends on your individual situation, including how quickly your blood cells recover and how well you are. You may stay in hospital for a few weeks after a stem cell transplant. Find out what happens when you have a stem cell transplant.Platelets help to clot the blood to prevent bleeding. White blood cells are part of your immune system and help to fight infection. Red blood cells contain haemoglobin which carries oxygen around the body. These stem cells develop into red blood cells, white blood cells and platelets. Stem cells are very early cells made in the bone marrow. Bone marrow is a spongy material that fills the bones. Your specialist will talk through the options with you. Stem cell transplants are very intensive treatments, and can cause severe side effects. ![]() Remission means that there is no sign of active myeloma. Your doctor might recommend intensive treatment to improve the chance of getting a complete response, which is called CR or remission. Why you might have a stem cell transplant They are sometimes called stem cell rescue or intensive treatments. This is called having a stem cell transplant. ![]() High dose chemotherapy destroys cancer cells, but also damages the stem cells that make blood cells in the bone marrow. So if you need high dose treatment you need a way of replacing the stem cells that have been destroyed.
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